Dr. Caleb O. Lemley

Friend, M., Nicodemus, M. C., Cavinder, C. A., Lemley, C. O., Prince, P., Holtcamp, K., Swanson, R. 2024. Impact of Equine Interaction during Psychotherapy on Anxiety and Depression for Residential Treatment Program Patients Experiencing Substance Withdrawal. People and Animals: The International Journal of Research and Practice 7(1 (Article 3)).

Griffin, C. K., Lemley, C. O., Pohler, K. G., Sun, X., Lear, A. S. 2024. Characterization of placentome vascular perfusion in relation to pregnancy associated glycoproteins throughout gestation in pregnant beef heifers. Theriogenology 219:94-102.

Contreras-Correa, Z. E., Sánchez-Rodríguez, H. L., Arick, M. A., Muñiz-Colón, G., Lemley, C. O. 2024. Thermotolerance capabilities, blood metabolomics, and mammary gland hemodynamics and transcriptomic profiles of slick-haired Holstein cattle during mid lactation in Puerto Rico. Journal of Dairy Science 107(6):4017-4032.

Swanson, R. M., Messman, R. D., Dobbins, T. W., Contreras-Correa, Z. E., Arick, M. A., Sidelinger, D. R., King, H., Lemley, C. O. 2024. Seminal plasma uterine priming alters uterine transcriptomics and negatively impacts embryo growth and uterine artery resistance but not offspring liver transcriptomics in beef cattle. Journal of Animal Science 102(skae300).

Harman, A. R., Contreras-Correa, Z. E., Messman, R. D., Swanson, R. M., Lemley, C. O. 2023. Maternal nutrient restriction and dietary melatonin alter neurotransmitter pathways in placental and fetal tissues. Placenta 131:13-22.

Farnlacher, E., Friend, M., Holtcamp, K., Nicodemus, M. C., Swanson, R., Lemley, C. O., Cavinder, C. A., Prince, P. 2023. Cortisol concentrations in substance use disorder patients undergoing psychotherapy incorporating equine interaction compared to cognitive behavioral therapy. Journal of Equine Veterinary Science

Friend, M., Nicodemus, M. C., Cavinder, C. A., Lemley, C. O., Prince, P., Holtcamp, K., Swanson, R. 2023. Physiology of human-horse interactions during substance withdrawal within psychotherapy participants. Comparative Exercise Physiology

Messman, R. D., Lemley, C. O. 2023. Bovine neonatal microbiome origins: A review of proposed microbial community presence from conception to colostrum. Translational Animal Science

Reid, D., Geary, T., Zeszeski, A., Waterman, R., Van Emon, M., Messman, R., Devost-Burnett, D. D., Lemley, C. O. 2023. Effects of prenatal and postnatal melatonin supplementation on overall performance, male reproductive performance, and testicular hemodynamics in beef cattle. Journal of Animal Science

Contreras-Correa, Z., Messman, R., Swanson, R., Lemley, C. O. 2023. Melatonin in health and disease: A perspective for livestock production. Biomolecules

Messman, R. D., Swanson, R. M., Ganapathi Shanmugam, S., Lemley, C. O. 2023. PSXIV-11 Evaluating the Inoculating Bacterial Communities Within the Bovine Dam and Neonate After Applying an Ablation Technique to the Dam Vaginal Microbiome Prior to Parturition. Journal of Animal Science 101(Supplement\_3):544--545.

Reid, D. S., Burnett, D. D., Contreras-Correa, Z. E., Lemley, C. O. 2022. Differences in bovine placentome blood vessel density and transcriptomics in a mid to late-gestating maternal nutrient restriction model. Placenta 117:122-130.

Mazinani, M., Contreras-Correa, Z. E., Behzadan, V., Gopal, S., Lemley, C. O. 2022. Effects of maternal nutrient restriction and melatonin supplementation on cardiomyocyte cell development parameters using machine learning techniques. Animals 12(1818).

Silva, F. A., Camacho , L. E., Lemley, C. O., Hallford, D. M., Swanson, K. C., Vonnahme , K. A. 2022. Effects of nutrient restriction and subsequent realimintation in pregnant beef cows: Maternal endocrine profile, umbilical hemodynamics, and mammary gland development and hemodynamics. Theriogenology 191:109-121.

Swanson, R. M., Contreras-Correa, Z. E., Dinh, T., King, E. H., Sidelinger, D., Devost-Burnett, D. D., Lemley, C. O. 2022. Melatonin supplementation alters maternal and fetal amino acid concentrations and placental nutrient transporters in a nutrient restriction bovine model. Metabolites 12(1208).

Contreras-Correa, Z. E., Cochran, T., Metcalfe, A., Devost-Burnett, D. D., Lemley, C. O. 2022. Seasonal and temporal variation in the placenta during melatonin supplementation in a bovine compromised pregnancy model. Journal of Animal Science 100(12).

Trotta, R. J., Lemley, C. O., Vonnahme , K. A., Swanson, K. C. 2021. Effects of nutrient restriction and melatonin supplementation from mid- to late-gestation on maternal and fetal small intestinal carbohydrase activities in sheep. Domestic Animal Endocrinology 74.

Dysart, L., Messman, R., Crouse, A., Lemley, C. O., Larson, J. E. 2021. Effects of administration of exogenous estradiol benzoate on follicular, luteal, and uterine hemodynamics in beef cows. Animal Reproduction Science

Sanford, C., Owen, M., McCarty, K., Canal, L., Schulmeister, T., Oosthuizen , N., Fontes , P., Lemley, C. O., Bromfield , J., DeLorenzo, N., Lamb , C. 2021. Effects of Administering Exogenous Bovine Somatotropin During the First Trimester of Pregnancy Altered Uterine Hemodynamics in Suckled Beef Cows. Frontiers in Animal Science 2:744790.

Contreras-Correa, Z. E., Messman, R. D., Sidelinger, D. R., Heath King, E., Sánchez-Rodríguez, H. L., Burnett, D. D., Lemley, C. O. 2021. Melatonin alters bovine uterine artery hemodynamics, vaginal temperatures, and fetal morphometrics during late gestational nutrient restriction in a season-dependent manner. Journal of Animal Science 99(9):9.

Messman , R., Contreras-Correa , Z., Paz , H., Lemley, C. O. 2021. Melatonin-induced changes in the bovine vaginal microbiota during maternal nutrient restriction. Journal of Animal Science 99:5.

Sanford, C., Owen, M., Oosthuizen, N., Fontes, P., Vonnahme , K., Nelson, M., Reyaz , A., Lemley, C. O., DiLorenzo, N., Lamb , C. 2021. Effects of administering exogenous bovine somatotropin to beef heifers during the first trimester on conceptus development as well as steroid and eicosanoid metabolizing enzymes. Journal of Animal Science 99:3.

Trotta, R., Lemley, C. O., Vonnahme , K., Swanson , K. 2021. Effects of nutrient restriction and melatonin supplementation from mid- to late-gestation on maternal and fetal small intestinal carbohydrase activities in sheep. Domestic Animal Endocrinology 74:106555.

Owen, M. P., Northrop, E. J., Rich, J. J., Perry, G. A., Messman, R. D., Dinh, T. T., McCarty, K. J., Yang, J., Wan, D., Lemley, C. O. 2020. Oxylipin concentrations in bovine corpora lutea during maternal recognition of pregnancy. Theriogenology 142:384-389.

Lemley, C. O., Bowers, K. J., Yankey, K. C., Tu, M. L., Hart, C. G., Steadman, C. S., McCarty, K. J., Owen, M. P. 2020. Investigating ovine placentome blood perfusion using power flow Doppler ultrasonography. Small Ruminant Research 184.

Contreras-Correa, Z. E., Lemire, R. L., Devost-Burnett, D. D., Lemley, C. O. 2020. Temporal transcript abundance of clock genes, angiogenic factors, and nutrient sensing genes in bovine placental explants. Theriogenology 151:74-80.

Messman, R. D., Contreras-Correa, Z. E., Paz Manazno, H., Perry, G., Lemley, C. O. 2020. Vaginal bacterial community composition and concentrations of estradiol at time of artificial insemination in Brangus heifers. Journal of Animal Science 98(6).

Ferjak, E. N., Cavinder, C. A., Theradiyil Sukumaran, A., Devost-Burnett, D. D., Lemley, C. O., Dinh, T. T. 2019. Fatty acid composition of mesenteric, cardiac, abdominal, intermuscular, and subcutaneous adipose tissues from horses of three body condition scores. Livestock Science 223:116-123.

Owen, M. P., Ferjak, E. N., Cavinder, C. A., McCarty, K. J., Yankey , K. C., Hart, C. G., Devost-Burnett, D. D., Dinh, T. T., Lemley, C. O. 2018. Effects of body condition score (BCS) on steroid- and eicosanoid-metabolizing enzyme activity in various mare tissues during winter anoestrus. Reproduction in Domestic Animals 53:296-303.

Owen, M. P., McCarty, K. J., Hart, C. G., Steadman, C. S., Lemley, C. O. 2018. Endometrial blood perfusion as assessed using a novel laser Doppler technique in Angus cows. Animal Reproduction Science 190:119-126.

Lemley, C. O., Camacho, L. E., Hallford, D. M., Vonnahme , K. A. 2018. Uteroplacental secretion of progesterone and estradiol-17beta in an ovine model of intrauterine growth restriction. Animal Reproduction Science 193:68-78.

Hart, C. G., Voelz, B. E., Brockus, K. E., Lemley, C. O. 2018. Hepatic steroid inactivating enzymes, hepatic portal blood flow, and corpus luteum blood perfusion in cattle. Reproduction in Domestic Animals 53:751-758.

Camacho, L. E., Lemley, C. O., Dorsam, S. T., Swanson, K. C., Vonnahme , K. A. 2018. Effects of maternal nutrient restriction followed by realimentation during early and mid-gestation in beef cows. II. Placental development, umbilical blood flow, and uterine blood flow responses to diet alterations. . Theriogenology 116:1-11.

Lemley, C. O., Hart, C. G., Lemire, R. L., King, E. H., Hopper, R. M., Park, S. B., Rude, B. J., Burnett, D. D. 2018. Maternal nutrient restriction alters uterine artery hemodynamics and placentome vascular density in Bos indicus and Bos taurus. Journal of Animal Science 96:4823-4834.

McCarty, K. J., Owen, M. P., Hart, C. G., Thompson, R. C., Burnett, D. D., King, E. H., Hopper, R. M., Lemley, C. O. 2018. Effect of chronic melatonin supplementation during mid to late gestation on maternal uterine artery blood flow and subsequent development of male offspring in beef cattle. Journal of Animal Science 96(12):5100-5111.

Muth-Spurlock, A. M., Dix, J. A., Coleson, M. P., Hart, C. G., Lemley, C. O., Schulmeister, T. M., Lamb, G. C., Larson, J. E. 2017. The effect of follicular wave on fertility characteristics in beef cattle. Journal of Animal Science 95:866-874.

Cain, A. J., Lemley, C. O., Walters, K., Christiansen, D. L., King, E. H., Hopper, R. M. 2017. Pre-breeding beef heifer management and season affect mid to late gestation uterine artery hemodynamics. Theriogenology 87:9-15.

Lemley, C. O., Vonnahme , K. A. 2017. Alterations in uteroplacental hemodynamics during melatonin supplementation in sheep and cattle. Journal of Animal Science 95:2211-2221.

Keomanivong, F. E., Camacho, L. E., Lemley, C. O., Kuemper, E. A., Yunusova, R. D., Barowicz, P. P., Kirsch, J. D., Vonnahme, K. A., Caton, J. S., Swanson , K. C. 2017. Effects of realimentation after nutrient restriction during mid- to late-gestation on pancreatic digestive enzymes, serum insulin and glucose levels, and insulin containing cell cluster morphology. Journal of Animal Physiology and Animal Nutrition 101:589-604.

Lemley, C. O. 2017. Investigating reproductive organ blood flow and blood perfusion to ensure healthy offspring. Animal Frontiers 7:18-24.

Hodge, L. B., Rude, B. J., Dinh, T. T., Lemley, C. O. 2017. Effect of ω-3 Fatty Acid Supplementation to Gestating and Lactating Mares: On Milk IgG, Mare and Foal Blood Concentrations of IgG, Insulin and Glucose, Placental Efficiency, and Fatty Acid Composition of Milk and Serum From Mares and Foals. Journal of Equine Veterinary Science 51:70-78.

Brockus, K. E., Hart, C. G., Gilfeather, C. L., Fleming, B. O., Lemley, C. O. 2016. Dietary melatonin alters uterine artery hemodynamics in pregnant Holstein heifers. Domestic Animal Endocrinology 55:1-10.

Cline, G. F., Muth-Spurlock, A. M., Voelz, B. E., Lemley, C. O., Larson, J. E. 2016. Evaluating blood perfusion of the corpus luteum in beef cows during fescue toxicosis. Journal of Animal Science 94:90-95.

Keomanivong, F. E., Lemley, C. O., Camacho, L. E., Yunusova, R., Borowicz, P. P., Caton, J. S., Meyer, A. M., Vonnahme, K. A., Swanson, K. C. 2016. Influence of nutrient restriction and melatonin supplementation of pregnant ewes on maternal and fetal pancreatic digestive enzymes and insulin-containing clusters. Animal 10:440-448.

Brockus, K. E., Hart, C. G., Fleming, B. O., Smith, T., Ward, S. H., Lemley, C. O. 2016. Effects of supplementing Holstein heifers with dietary melatonin during late gestation on growth and cardiovascular measurements of their offspring. Reproduction in Domestic Animals 51:240-247.

Prezotto, L. D., Camacho, L. E., Lemley, C. O., Keomanivong, F. E., Caton, J. S., Vonnahme, K. A., Swanson, K. C. 2016. Nutrient restriction and realimentation in beef cows during early- and mid-gestation and maternal and fetal hepatic and small intestinal in vitro oxygen consumption. Animal 10:829-837.

Gilfeather, C. L., Lemley, C. O. 2016. Effects of interferon-tau and steroids on cytochrome P450 activity in bovine endometrial epithelial cells. Reproduction in Domestic Animals 51:415-420.

Kennedy, V. C., Mordhorst, B. R., Gaspers, J. J., Bauer, M. L., Swanson, K. C., Lemley, C. O., Vonnahme , K. A. 2016. Supplementation of corn dried distiller’s grains plus solubles to gestating beef cows fed low-quality forage: II. Impacts on uterine blood flow, circulating estradiol-17β and progesterone and hepatic steroid metabolizing enzyme activity. Journal of Animal Science 94:4619-4628.

Voelz, B. E., Cline, G. F., Hart, C. G., Lemley, C. O., Larson, J. E. 2015. Effect of 2 corpora lutea on blood perfusion, peripheral progesterone, and hepatic steroid-inactivating enzymes in dairy cattle. Journal of dairy science 98(1):288-94.

Lekatz, L. A., Swanson, T. J., Camacho, L. E., Yunusova, R., Borowicz, P. P., Caton, J. S., Meyer, A. M., Lemley, C. O., Vonnahme, K. A. 2015. Maternal metabolizable protein restriction during late gestation on uterine and umbilical blood flows and maternal and fetal amino acid concentrations near term in sheep. Animal Reproduction Science 158:115-125.

Yunta, C., Vonnahme, K. A., Mordhost, B. R., Hallford, D. M., Lemley, C. O., Parys, C., Bach, A. 2015. Arginine supplementation between 41 to 146 days of pregnancy reduces uterine blood flow in dairy heifers. Theriogenology 84:43-50.

Vonnahme, K. A., Lemley, C. O., Caton, J. S., Meyer, A. M. 2015. Impacts of maternal nutrition on vascularity of nutrient transferring tissues during gestation and lactation. Nutrients 7:3497-3523.

Eifert, A. W., Wilson, M. E., Vonnahme, K. A., Camacho, L. E., Borowicz, P. P., Redmer, D. A., Romero, S., Dorsam, S., Haring, J., Lemley, C. O. 2015. Effect of melatonin or maternal nutrient restriction on vascularity and cell proliferation in the ovine placenta. Animal Reproduction Science 153:13-21.

Gifford, C. A., Branham, K. A., Ellison, J. O., Gomez, B. I., Lemley, C. O., Hart, C. G., Krehbiel, C. R., Bernhard, B. C., Maxwell, C. L., Goad, C. L., Hallford, D. M., Hernandez-Gifford, J. A. 2015. Effect of anabolic implants on adrenal cortisol synthesis in feedlot beef cattle implanted early or late in the finishing phase. Physiology & Behavior 138:118-123.

Larson, J. E., Voelz, B. E., Hardin, D. K., Lemley, C. O. 2014. Nutritional characteristics of the dairy cow during early gestation and subsequent growth and cardiac measurements of her offspring. Am J Anim Vet Sci 9(3):146-154.

Hart, C. G., Camacho, L. E., Swanson, K. C., Vonnahme, K. A., Lemley, C. O. 2014. Hepatic steroid metabolizing enzyme activity during early, mid, and late bovine pregnancy. Domestic Animal Endocrinology 49:31-38.

Lemley, C. O., Meyer, A. M., Neville, T. L., Hallford, D. M., Camacho, L. E., Maddock-Carlin, K. R., Wilmoth, T. A., Wilson, M. E., Perry, G. A., Redmer, D. A., Reynolds, L. P., Caton, J. S., Vonnahme, K. A. 2014. Dietary selenium and nutritional plane alters maternal endocrine profiles during pregnancy and lactation. Domestic Animal Endocrinology 46:1-11.

Shukla, P., Ghatta, S., Dubey, N., Lemley, C. O., Johnson, M. L., Modgil, A., Vonnahme, K. A., Caton, J. S., Reynolds, L. P., Sun, C., O'Rourke, S. T. 2014. Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries. American Journal of Physiology – Heart and Circulatory Physiology 307:H134-H142.

Shukla, P., Lemley, C. O., Dubey, N., Meyer, A. M., O'Rourke, S. T., Vonnahme, K. A. 2014. Effect of maternal nutrient restriction and melatonin supplementation from mid to late gestation on vascular reactivity of maternal and fetal placental arteries. Placenta 35:461-466.

Prezotto, L. D., Lemley, C. O., Camacho, L. E., Doscher, F. E., Meyer, A. M., Caton, J. S., Awda, B. J., Vonnahme, K. A., Swanson, K. C. 2014. Effects of nutrient restriction and melatonin supplementation on maternal and fetal hepatic and small intestinal energy utilization. Journal of Animal Physiology and Animal Nutrition 98:797-807.

Camacho, L. E., Lemley, C. O., Prezotto, L. D., Bauer, M. L., Freetly, H. C., Swanson, K. C., Vonnahme, K. A. 2014. Effects of maternal nutrient restriction followed by re-alimentation during mid-gestation on uterine blood flow in beef cows. Theriogenology 81:1248-1256.

Camacho, L. E., Lemley, C. O., Van Emon, M. L., Caton, J. S., Swanson, K. C., Vonnahme, K. A. 2014. Effects of maternal nutrient restriction followed by realimentation during early and midgestation on beef cows. I. Maternal performance and organ weights at different stages of gestation. Journal of Animal Science 92:520-529.

Reynolds, L. P., Vonnahme, K. A., Lemley, C. O., Redmer, D. A., Grazul-Bilska, A. T., Borowicz, P. P., Caton, J. S. 2013. Maternal stress and placental vascular function and remodeling. Current Vascular Pharmacology 11:564-593.

Lemley, C. O., Camacho, L. E., Vonnahme, K. A. 2013. Uterine infusion of melatonin or melatonin receptor antagonist alters ovine feto-placental hemodynamics during mid-gestation. Biology of Reproduction 89:40, 1-9.

Lemley, C. O., Camacho, L. E., Meyer, A. M., Kapphahn, M., Caton, J. S., Vonnahme, K. A. 2013. Dietary melatonin supplementation alters uteroplacental amino acid flux during intrauterine growth restriction in ewes. Animal 7:1500-1507.

Vonnahme, K. A., Lemley, C. O., Shukla, P., O'Rourke, S. T. 2013. Placental programming: How the maternal environment can impact placental function. Journal of Animal Science 91:2467-2480.

Long, N. M., Tuersunjiang, N., George, L. A., Lemley, C. O., Ma, Y., Murdoch, W. J., Nathanielsz, P. W., Ford, S. P. 2013. Maternal nutrient restriction in the ewe from early to midgestation programs reduced steroidogenic enzyme expression and tended to reduce progesterone content of corpora lutea, as well as circulating progesterone in nonpregnant aged female offspring. Reproductive Biology and Endocrinology 11:34.

Koch, J. M., Lemley, C. O., Magness, R. R., Wilson, M. E. 2013. Periconceptional growth hormone treatment alters early uterine environment. . Open Journal of Animal Sciences 3:121-126.

Mottet, R. S., Lemley, C. O., Vonnahme, K. A., Berg, E. L. 2013. Lipoic acid decreases progesterone clearance in ovariectomized ewes. . Animal Reproduction 10:112-118.

Lemley, C. O., Meyer, A. M., Camacho, L. E., Neville, T. L., Newman, D. J., Caton, J. S., Vonnahme, K. A. 2012. Melatonin supplementation alters uteroplacental hemodynamics and fetal development in an ovine model of intrauterine growth restriction. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 302(4):R454-R467.

Vonnahme, K. A., Lemley, C. O. 2012. Programming the offspring through altered uteroplacental hemodynamics: how maternal environment impacts uterine and umbilical blood flow in cattle, sheep and pigs. Reproduction, Fertility and Development 24(1):97-104.

Lemley, C. O., Wilson, M. E. 2010. Effect of cytochrome P450 and aldo-keto reductase inhibitors on progesterone inactivation in primary bovine hepatic cell cultures. Journal of Dairy Science 93:4613-4624.

Lemley, C. O., Vonnahme, K. A., Tager, L. R., Krause, K. M., Wilson, M. E. 2010. Diet induced alterations in hepatic progesterone (P4) catabolic enzyme activity and P4 clearance rate in lactating dairy cows. Journal of Endocrinology 205:233-241.

Lemley, C. O., Wilmoth, T. A., Tager, L. R., Krause, K. M., Wilson, M. E. 2010. Effect of a high cornstarch diet on hepatic cytochrome P450 2C and 3A activity and progesterone half-life in dairy cows. Journal of Dairy Science 93:1012-1021.

O'Neil, M. R., Lardy, G. P., Wilson, M. E., Lemley, C. O., Reynolds, L. P., Caton, J. S., Vonnahme, K. A. 2009. Estradiol-17β and linseed meal interact to alter visceral organ mass and hormone levels from ovariectomized ewes. Domestic Animal Endocrinology 37:148-158.

Lemley, C. O., Koch, J. M., Blemings, K. P., Wilson, M. E. 2009. Alterations in progesterone catabolic enzymes, CYP2C and CYP3A, in hepatocytes challenged with insulin and glucagon. Journal of Animal and Veterinary Advances 8:39-46.

Lemley, C. O., Koch, J. M., Blemings, K. P., Krause, K. M., Wilson, M. E. 2008. Concomitant changes in progesterone catabolic enzymes, cytochrome P450 2C and 3A, with plasma insulin concentrations in ewes supplemented with sodium acetate or sodium propionate. Animal 2:1223-1229.

Lemley, C. O., Butler, S. T., Butler, W. R., Wilson, M. E. 2008. Short communication: insulin alters hepatic progesterone catabolic enzymes, cytochrome P450 2C and 3A, in dairy cows. Journal of Dairy Science 91:641-645.